The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may result in an increase in methadone plasma concentrations, which could cause probably fatal respiratory depression. Additionally, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also result in a rise in